We've Invested In Opharmic UniBioscience JV Xandar Kardian Innovac Valora Oncoustics Endiatx Spiral Tx Heranova Thrive Bioscience Pacegenix Pilatus Memora Pebble Launchpad KA Imaging SMT Phase Scientific HKU-Miles
Explore our diverse portfolio of innovative ventures shaping the future. Whether home grown in Hong Kong, or planted from Stanford or Shanghai, our projects redefine medicine. Our companies know no borders and are committed to the betterment of humanity.
Opharmic
OPHARMIC TECHNOLOGY, a company from the Hong Kong University of Science and Technology, creates technology using ultrasound for eye treatments. Their method can safely deliver chemical and biological molecules (up to 70kDa) through the eye’s outer layer without needles, and it has been shown to work for many types of drugs and eye problems. Opharmic’s pioneering drug delivery technology has attracted major pharmaceutical companies’ interest, and the company has initiated collaborations with these pharma companies to co-develop ophthalmological therapies.
UniBioscience JV
Pebble is developing a new asset in collaboration with Uni-Bio Science Group Limited (SEHK: 0690). By harnessing sister company Great Bay Bio’s proprietary AI-enabled CMC technology, we are able to develop optimized therapeutic antibodies targeting obesity and diabetes that reduce weight, improve mental status, and increase muscle gain all at the same time. The long term vision is to co-develop best-in-class cures for aging-related indications.
Xandar Kardian
XANDAR KARDIAN is a leader in remote health monitoring, utilizing FDA-cleared IR-UWB radar technology for vital signs and disease monitoring. The company has secured significant orders and formed partnerships with key industry players, aiming to transform the standard of care. Pebble is collaborating with Xandar Kardian to pursue regulatory approvals in China.
Innovac
INNOVAC THERAPEUTICS is a clinical-stage biotech company dedicated to developing personalized mRNA cancer vaccines for unmet medical needs. Innovac has incorporated the mRNA tail-modifying technology developed by HKUST Dr. Becki Kuang to further improvise its mRNA platform. The lead assets of Innovac are the personalised mRNA cancer vaccine for multiple solid tumor indications and the therapeutic vaccine for chronic HSV-2 infection.
Valora
VALORA THERAPEUTICS is a pre-clinical stage biotech developing innovative biologics unlocking the therapeutic potential of glyco-immune checkpoint modulation. With the pioneering biologics platform invented by 2022 Nobel Laureate Prof. Carolyn Bertozzi and exceptional management team featuring the founder of Rakuten Medical, Valora is engineering its flagship antibody-lectin(AbLec) chimeras for oncology and autoimmune diseases.
Oncoustics
ONCOUSTICS, a San Francisco-based corporation, established with the goal of revolutionaizing medical diagnostics through the use of raw acoustic data and AI. Its OnX Liver Assessment Solution offers a cost-effective and noninvasive liver diagnosis alternative to traditional biopsies and MRIs, and utilizes a cutting-edge Machine Learning approach to analyze acoustic data. The company plans to expand its platform to support various medical applications, including prostate cancer, thyroid cancer, and women’s health.
Endiatx
ENDIATX, an early-stage biotech company supported by Mayo Clinic dedicated to pioneering remote diagnosis by developing a swallowable mini robot. Endiatx’s flagship technology, Pillbot, is a pill camera that can be manoeuvred in the stomach remotely, enabling diagnosis without hospitalization or sedation. Endiatx is well-positioned to capture the remote GI diagnosis market in the near future with pending FDA and NMPA clearance.
Spiral Tx
SPIRAL THERAPEUTICS is a San Francisco-based clinical-stage company dedicated to protecting hearing and treating ear diseases. Spiral addresses hearing loss problems by developing a minimally invasive method of drug delivery to the right place of inner ear, for the right duration. Spiral’s lead asset, SPT-2101, is a sustained-release steroid formulation for Meniere’s disease.
Heranova
HERANOVA is a company solely focused on Women’s Health by developing and providing innovative, multi-modality solutions to address unmet medical needs. Heranova is developing first-in-class diagnostic, drug programs and device programs to target critical women health conditions, including reproductive, maternal and menopausal health.
Thrive Bioscience
Thrive is Boston-based company developing next-generation automated cell culturing hardware + microscopy software and AI. By standardizing how cells are looked at, imaged, and created, Thrive is able to for the first time ever, train an AI model on cell morphology. High quality data is critical — no garbage in, garbage out!
Pacegenix
Pacegenix is project incubated by Genesis Biocapital, developing a new type of first-in-class prodrugs for Hypertrophic Cardiomyopathy and other cardiovascular indications. With a pipeline still primarily in stealth, Pebble is working with them to recruit patients in China and pursue simultaneous regulatory filing in the US and China.
Pilatus
Pilatus is a Swiss-based company developing a first-in-class CD36 Blocking Antibody to target ”immune-cold” solid tumours. The company has already received FDA Orphan Drug Designation for HCC and Cholangiocarcinoma. We are strategically working with Pilatus to establish a HK and China strategy.
Memora
Memora is a preclinical company led by a CUHK Prof. Owen Ko. Based on Prof. Ko’s innovative insights and long-standing neurology research, Memora seeks to develop new bispecific antibody-drug conjugate targeting GLP-1 signalling pathway to counteract neuroinflammation, and hence mitigate and reverse neurodegenerative diseases such as Parkinson’s Disease, Dementia and Alzheimer’s Disease.
KA Imaging
KA Imaging is a leading developer of advanced X-ray imaging technologies that enhance diagnostic precision across medical, veterinary, security, scientific, industrial, and non-destructive testing (NDT) applications. The company specializes in spectral and phase contrast X-ray imaging, powered by deep AI analytics, offering solutions that improve safety, streamline workflows, and deliver greater image clarity.
SMT
PHASE Scientific
HKU MILES
Project MILES is pioneering the integration of NIR-II fluorescence imaging into surgeries, led by Stanford’s Professor Emeritus Hongjie Dai. This technology provides surgeons with real-time, high-resolution imaging, improving precision by enhancing tissue and tumor visualization. Pebble, in collaboration with Tigermed and Tigermed-Jyton, is working with Prof. Dai to chart the best clinical path for this groundbreaking innovation.
Pentepebble
Pentepebble (PP) is the former portfolio of our management team – consider it Pebble’s track record. PP is a Hong Kong company that invests in Healthcare+ companies connected to the Greater Bay Area (GBA). From bench to bedside, zero to IPO, they help their companies (aka “pebbles”) achieve milestones with rigor, virtue, and expediency.
